This study presents cultural classification of illness and disease as an insight into the comprehension of the behaviours and attitudes of people towards Coronavirus disease. The researchers depend largely on data gathered through rapid research approach in some cities in Yorùbá land in the southwest geopolitical zone of Nigeria, where Facebook, WhatsApp, phoning, and quick in-depth interviews, ethno-botanical survey/analysis of some anti-microbial herbs and case analysis were held. The study brings to light conflicting and contrasting opinions of COVID-19, which engender divergent systems of care and prevention among which are biomedical against preternatural causation and application of local herbs in competition with globalised western health care techniques. So the study proposes that, for proper understanding and formulation of care and preventive methods against Coronavirus, accommodation of local traditions within the context of globalised health culture is necessary.